Journal article
The role of naturally acquired antimalarial antibodies in subclinical Plasmodium spp. infection
K O'Flaherty, M Roe, FJI Fowkes
Journal of Leukocyte Biology | OXFORD UNIV PRESS | Published : 2022
Abstract
Undetected subclinical Plasmodium spp. infections are a significant barrier to eliminating malaria. In malaria-endemic areas, naturally acquired antimalarial antibodies develop with repeated infection. These antibodies can confer protection against the clinical manifestations of Plasmodium spp. infection in highly exposed populations, and several distinct functional antibody mechanisms have been defined in the clearance of Plasmodium parasites. However, the role of antimalarial antibodies during subclinical infection is less well defined. In this review, we examine the development and maintenance of antibody responses and the functional mechanisms associated with clinical protection, highlig..
View full abstractRelated Projects (2)
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (project grant 1161190 and Career Development Fellowship 1166753 to F. J. I. F); the Australian Centre for Research Excellence in Malaria Elimination (Centres for Research Excellence grant 1134989 to F. J. I. F); Independent Research Institutes Infrastructure Support Scheme to Burnet Institute and a Victorian State Government Infrastructure Support grant to Burnet Institute, and the Australian Commonwealth Government (Australian Government Research Training Program scholarship to M. S. R.).